Industrial Advisory Board Meeting - Jan 2020

Research Update Meeting – Jan 2020

October 17, 2019

The workshop brought together collaborators from academia and industry to discuss progress and prospectives in Point of Care (PoC) sensing platforms and techniques. 

Lecture Program

Nazir Kherani: Multiwavelength SERS: Toward Rapid Point-of-Care Sensing

Ravi Selvaganapathy: Microfluidics for Sepsis Diagnosis at the Bedside

Steward Aitchison: Chip-based Cytometry for Cell and Bead Assays

Carolyn Ren: Microfluidic-based Methods for Enrichment of Low Abundant Proteins and Microwave Enabled Sample Preparation

Yu Sun: Detection of Fetal-Maternal Hemorrhage

Naomi Matsuura: Minimally-invasive Sampling of Diseased Tissue in vivo

Aaron Wheeler: POC Diagnostic Field Trials in Africa

Paul Smith: Angle Biosciences

Tiemen Huang: Advanced Electrophoresis

Sam Visaisouk: Sigma Bio-instruments

Bradford Behr: Tornado

Lynn McNeil/Ryan Hayman: Chip Care

Anna Zavodni: PoC Testing: Unmet Clinical Needs

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April 23, 2019

Program

On Apr 23 2019, the first workshop was held at The University of Toronto on the NanoPhotonic Sensing ORF project with the various PIs party to the project. The focus of this meeting was to review and discus the range of technical expertise (nano- and microfabrication, microfluidics and sensing) among the collaborating research groups (i.e. PIs and coPIs) and thereby define a workplan to address the first-year milestones of the ORF-RE project.

The primarily goal of the current ORF-RE program is to research, develop and prototype, and commercialize high sensitivity multiplexing rapid blood analyzers which can be deployed at the point-of-care. This project involves four research thrusts that culminate in the development and integration of key technology elements comprising of: NPS elements, state-of-the-art microfluidic devices for blood processing, portable optical imaging systems and spectrometers all packed in a portable instrument with and intuitive user interface. Several thrusts were initially defined by the ORF team to determine the overall workflow for the 5year duration of this program with the first thrust aiming to develop integrated nanophotonic-microfluidic devices.

During the kick-off meeting of Apr23th, all participating PIs and coPIs presented an overview of their research activities and how those activities could be redirected towards achieving the objectives of the first thrust. To this end,

1. It was decided that during the first 24 months of the program team Kherani (Electrical Engineering Dep., University of Toronto) and Selvaganapathy (Mechanical Engineering Dep., McMaster University) will establish the integration and develop low-cost methods and procedures for mass fabrication of the nanophotonic sensing elements and the microfluidic devices.

2. It was also discussed that the detection limits (sensitivity and specificity) of the integrated devices for clinically relevant pure pathogens and biomarkers in a dynamic flow configuration will be subsequently evaluated and documented by team Matsuura-Zavodni-Robichaud-Wang (Medical Imaging Dep, University of Toronto-Sunnybrook Hospital-Hamilton General Hospital-Mount Sinai Hospital) using surface enhanced Raman spectroscopy (SERS) and surface enhanced fluorescence (SEF) imaging.

3. It was planned that all effort mentioned above will be carried out in collaboration with (i) Tornado Spectral Systems, providing Raman spectrometers, assisting with hardware integration and data analysis, (ii) ChipCare Corporation, providing fluorescence imaging systems and assisting with hardware integration and data analysis, (iii) Angle Biosciences, providing capture reagents for NPS element functionalization when working with specimens with extremely low concentration, and (iv) in consultation with University Health Network (UHN), Sunnybrook hospital, Mt. Sinai hospital, Hamilton General hospital, and Massachusetts General hospital.

4. In parallel and during the first 24 months of the ORF program, team Aitchison (Electrical Engineering Dep., University of Toronto), Sun (Mechanical engineering, University of Toronto) and Selavaganapathy will translate existing laboratory-based raw blood processing technologies onto a chip for portable and hand-held applications. These technologies include:

4.1 Dilution using microwave heating by team Aitchison and team Ren (Mechanical engineering, University of Waterloo).

4.2 Plasma separation using on-chip membrane by team Selvaganapathy and team Sun.

4.3 Abundant protein separation using reagents by team Ren in collaboration with AES company.

4.4 Blood cell separation using acoustic waves by team Selvaganapathy.

4.5 On-chip mixing to improve reagent-blood interaction by team Ren-Matsuura-Selvaganapathy in collaboration with industry partner ChipCare.

Research updates corresponding to the objectives defined during the kick-off meeting will be presented and reviewed during the next meeting during the first Point of Care Workshop held on October 17 2019 at University of Toronto.